β adrenergic receptor

体外活性：辛弗林是一种常用于减肥的化合物。辛弗林作为麻黄碱的替代品已广受欢迎。含有苦橙或辛弗林的产品被怀疑会引起心血管不良反应。辛弗林可以通过刺激 AMPK 活性来刺激葡萄糖消耗（Glut4 依赖性葡萄糖摄取），而不管 L6 骨骼肌细胞中胰岛素刺激的 PI3 激酶-Akt 活性如何。

辛弗林（1 mg/kg；口服强饲；持续 8 天；PVL 和 BDL 大鼠）显着改善 PVL 和 BDL 大鼠的高动力状态。辛弗林治疗可显着降低PVL和BDL大鼠的门静脉压、门支血流和心脏指数，而平均动脉压和全身及门脉区域血管阻力则增强

Portal vein ligation (PVL) or bile duct ligation (BDL) rats
1 mg/kg per 12 hours
Oral gavage; for 8 days

[1]. Int J Med Sci . 2012;9(7):527-38.

[2]. Biochem Biophys Res Commun . 2012 Feb 24;418(4):720-4.

Synephrine is a phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen. It has a role as a plant metabolite and an alpha-adrenergic agonist. It is a phenethylamine alkaloid, a member of phenols and a member of ethanolamines. It is a conjugate base of a synephrinium.
Synephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine. The similarity of naming between m-synephrine and the unsubstituted form, synephrine, is a source of some confusion however m-synephrine refers to a related drug more commonly known as phenylephrine. While the compounds share some chemical and pharmacological similarities, they are in fact distinct chemical entities.
Synephrine has been reported in Citrus reticulata, Citrus hassaku, and other organisms with data available.
Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.

C9H13NO2

167.21

167.094

C, 64.65; H, 7.84; N, 8.38; O, 19.14

94-07-5

Synephrine hydrochloride; 5985-28-4; Synephrine hemitartrate; 16589-24-5; 614-35-7 (R-isomer)

7172

Off-white to light brown solid powder

1.2±0.1 g/cm3

341.1±27.0 °C at 760 mmHg

187 °C (dec.)(lit.)

163.4±14.3 °C

0.0±0.8 mmHg at 25°C

1.572

-0.03

52.49

3

3

3

12

122

0

OC1C=CC(C(CNC)O)=CC=1

YRCWQPVGYLYSOX-UHFFFAOYSA-N

InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

4-[1-hydroxy-2-(methylamino)ethyl]phenol

2934.99.03.00

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

配方 1 中的溶解度: ≥ 2.08 mg/mL (12.44 mM) (饱和度未知) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (这些助溶剂从左到右依次添加，逐一添加), 澄清溶液。
例如，若需制备1 mL的工作液，可将100 μL 20.8 mg/mL澄清DMSO储备液加入400 μL PEG300中，混匀；然后向上述溶液中加入50 μL Tween-80，混匀；加入450 μL生理盐水定容至1 mL。
*生理盐水的制备：将 0.9 g 氯化钠溶解在 100 mL ddH₂O中，得到澄清溶液。

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配方 2 中的溶解度: ≥ 2.08 mg/mL (12.44 mM) (饱和度未知) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (这些助溶剂从左到右依次添加，逐一添加), 澄清溶液。
例如，若需制备1 mL的工作液，可将 100 μL 20.8 mg/mL澄清DMSO储备液加入900 μL 20% SBE-β-CD生理盐水溶液中，混匀。
*20% SBE-β-CD 生理盐水溶液的制备（4°C，1 周）：将 2 g SBE-β-CD 溶解于 10 mL 生理盐水中，得到澄清溶液。

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配方 3 中的溶解度: ≥ 2.08 mg/mL (12.44 mM) (饱和度未知) in 10% DMSO + 90% Corn Oil (这些助溶剂从左到右依次添加，逐一添加), 澄清溶液。
例如，若需制备1 mL的工作液，可将 100 μL 20.8 mg/mL 澄清 DMSO 储备液加入到 900 μL 玉米油中并混合均匀。

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请根据您的实验动物和给药方式选择适当的溶解配方/方案：
1、请先配制澄清的储备液(如：用DMSO配置50 或 100 mg/mL母液(储备液));
2、取适量母液，按从左到右的顺序依次添加助溶剂，澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明，并不一定代表此产品 的实际溶解配方):
10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline);
假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀/澄清；向上述体系中加入50 μL Tween-80，混合均匀/澄清；然后继续加入450 μL ddH2O (或 saline)定容至 1 mL；
3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例;
4、 如产品在配制过程中出现沉淀/析出，可通过加热(≤50℃)或超声的方式助溶;
5、为保证最佳实验结果，工作液请现配现用！
6、如不确定怎么将母液配置成体内动物实验的工作液，请查看说明书或联系我们;
7、 以上所有助溶剂都可在 Invivochem.cn网站购买。