Kinase Inhibitor Library   中文名称: 激酶抑制剂库

Kinase Inhibitor Library is a collection of 895 compounds targeting various kinases such as protein kinases (e.g. KRAS, CDK, Akt, VEGFR, BTK, EGFR), lipid kinases (i.e. PI4K, PI3K, SK) and carbohydrate kinases (e.g. Hexokinase). Kinases play a key role various diseases like cancer. Kinase Inhibitor Library encompasses various newly reported compounds, approved and investigational drugs, and can be used for high throughput screening (HTS) and high content screening (HCS). The compounds are structurally diverse and pharmacologically active. The bioactivity and safety for a portion of the compounds have been confirmed by preclinical and clinical studies.

1. Form: Compounds in this library are in solid powder form or in pre-dissolved solutions.
2. Plate Layout:
96-well sample storage tube or 96-well plate with 1st and 12th column emptied.
384-well plate with the first 2 columns and the last 2 columns emptied.
3. Packaging & Container: 96- or 384-well plates sealed with peelable foil; 96-well format sample storage tube with screw cap.
4. Storage & Stability: store at -80°C for long term (1-2 years) and -20°C for short term (<1 year).
5. Shipping Condition: Blue ice for solutions; RT for solid powder form; or blue ice upon request.

Kinase Inhibitor Library is composed of 895 compounds targeting a wide range of kinases such as KRAS, TPK, CDK, Akt, c-Kit, PDGFR, HPK, Flt3, VEGFR, BTK, EGFR, PI4K, PI3K, SK etc. The Kinase Inhibitor Library can be used for identification of new therapeutic agents, targets, and action mechanisms.

[1]. J Exp Clin Cancer Res. 2019 Feb 6;38(1):56.