| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 500mg |
|
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| 1g |
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| Other Sizes |
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| 体外研究 (In Vitro) |
2-苯乙醇可激活肥皂中的防腐剂和香烟添加剂[1]。 2. 苯乙醇抑制革兰氏阴性染料的生长[1]。
|
|---|---|
| 体内研究 (In Vivo) |
在小鼠中，2-苯基乙醇（5%；呼吸）可减少抑郁样行为并增强焦虑样行为 [3]。
|
| 动物实验 |
Animal/Disease Models: 11weeks old male mice (C57BL/6) [3]
Doses: 5% (v/v) Route of Administration: inhalation; Experimental Results:It exerts an antidepressant-like effect, but may increase anxiety-like behaviors. |
| 药代性质 (ADME/PK) |
Metabolism / Metabolites
2-PHENYLETHANOL YIELDS PHENYLACETYLALDEHYDE IN RABBITS: SMITH JM ET AL, BIOCHEM J, 56, 320, 1954. /FROM TABLE/ Phenylethyl alcohol is oxidized almost entirely to the corresponding acid. Metabolites excreted in urine following oral doses of 0.2 to 0.3 g/kg to rabbits were phenaceturic acid, the glycine conjugate of phenylacetic acid, 42%; glucosidurinic acid, 5%; and an ether-soluble acid, probably phenylacetic acid, 19%. Only 66% of the original dose could be accounted for. /Phenylethyl alcohol/ ... beta-Phenylethyl alcohol is a substrate for ADH, with an initial rate of oxidation nearly as high as that of allyl alcohol and appreciably greater than that of ethanol. |
| 毒性/毒理 (Toxicokinetics/TK) |
Toxicity Data
LC50 (rat) > 500 mg/m3 Non-Human Toxicity Values LD50 Mouse oral 0.8-1.5 g/kg LD50 Guinea pig oral 0.4-0.8 g/kg LD50 Rat oral 1.79 and 2.46 g/kg LD50 Mouse ip injection 0.4-0.8 g/kg For more Non-Human Toxicity Values (Complete) data for 2-PHENYLETHANOL (7 total), please visit the HSDB record page. |
| 参考文献 | |
| 其他信息 |
2-phenylethanol is a primary alcohol that is ethanol substituted by a phenyl group at position 2. It has a role as a fragrance, a Saccharomyces cerevisiae metabolite, a plant metabolite, an Aspergillus metabolite and a plant growth retardant. It is a primary alcohol and a member of benzenes.
An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery. 2-Phenylethanol has been reported in Francisella tularensis, Camellia sinensis, and other organisms with data available. 2-phenylethanol is a metabolite found in or produced by Saccharomyces cerevisiae. An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery. See also: Moringa oleifera leaf oil (part of). Therapeutic Uses Anti-Infective Agents, Local; Disinfectants; Preservatives, Pharmaceutical Phenylethyl alcohol ... has been used in 0.5% conc as an antibacterial agent in ophthalmic solutions. /Phenylethyl alcohol/ |
| 分子式 |
C8H10O
|
|---|---|
| 分子量 |
122.17
|
| 精确质量 |
122.073
|
| CAS号 |
60-12-8
|
| 相关CAS号 |
2-Phenylethanol-d4;107473-33-6;2-Phenylethanol-d9;42950-74-3;2-Phenylethanol-d5;35845-63-7
|
| PubChem CID |
6054
|
| 外观&性状 |
Colorless to light yellow liquid
|
| 密度 |
1.0±0.1 g/cm3
|
| 沸点 |
218.2±8.0 °C at 760 mmHg
|
| 熔点 |
−27 °C(lit.)
|
| 闪点 |
102.2±0.0 °C
|
| 蒸汽压 |
0.1±0.5 mmHg at 25°C
|
| 折射率 |
1.536
|
| LogP |
1.36
|
| tPSA |
20.23
|
| 氢键供体(HBD)数目 |
1
|
| 氢键受体(HBA)数目 |
1
|
| 可旋转键数目(RBC) |
2
|
| 重原子数目 |
9
|
| 分子复杂度/Complexity |
65
|
| 定义原子立体中心数目 |
0
|
| SMILES |
O([H])C([H])([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
|
| InChi Key |
WRMNZCZEMHIOCP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2
|
| 化学名 |
2-phenylethanol
|
| 别名 |
Phenylethyl alcohol NSC 406252 NSC 406252 NSC406252 NSC-406252
|
| HS Tariff Code |
2934.99.9001
|
| 存储方式 |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| 运输条件 |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| 溶解度 (体外实验) |
H2O : ~20 mg/mL (~163.72 mM)
|
|---|---|
| 溶解度 (体内实验) |
配方 1 中的溶解度: 50 mg/mL (409.30 mM) in PBS (这些助溶剂从左到右依次添加，逐一添加), 澄清溶液; 超声助溶。
请根据您的实验动物和给药方式选择适当的溶解配方/方案： 1、请先配制澄清的储备液(如：用DMSO配置50 或 100 mg/mL母液(储备液)); 2、取适量母液，按从左到右的顺序依次添加助溶剂，澄清后再加入下一助溶剂。以 下列配方为例说明 (注意此配方只用于说明，并不一定代表此产品 的实际溶解配方): 10% DMSO → 40% PEG300 → 5% Tween-80 → 45% ddH2O (或 saline); 假设最终工作液的体积为 1 mL, 浓度为5 mg/mL: 取 100 μL 50 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀/澄清；向上述体系中加入50 μL Tween-80，混合均匀/澄清；然后继续加入450 μL ddH2O (或 saline)定容至 1 mL； 3、溶剂前显示的百分比是指该溶剂在最终溶液/工作液中的体积所占比例; 4、 如产品在配制过程中出现沉淀/析出，可通过加热(≤50℃)或超声的方式助溶; 5、为保证最佳实验结果，工作液请现配现用！ 6、如不确定怎么将母液配置成体内动物实验的工作液，请查看说明书或联系我们; 7、 以上所有助溶剂都可在 Invivochem.cn网站购买。 |
| 制备储备液 | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.1853 mL | 40.9266 mL | 81.8532 mL | |
| 5 mM | 1.6371 mL | 8.1853 mL | 16.3706 mL | |
| 10 mM | 0.8185 mL | 4.0927 mL | 8.1853 mL |
1、根据实验需要选择合适的溶剂配制储备液 (母液)：对于大多数产品，InvivoChem推荐用DMSO配置母液 (比如：5、10、20mM或者10、20、50 mg/mL浓度），个别水溶性高的产品可直接溶于水。产品在DMSO 、水或其他溶剂中的具体溶解度详见上”溶解度 (体外)”部分;
2、如果您找不到您想要的溶解度信息，或者很难将产品溶解在溶液中，请联系我们;
3、建议使用下列计算器进行相关计算（摩尔浓度计算器、稀释计算器、分子量计算器、重组计算器等）;
4、母液配好之后，将其分装到常规用量，并储存在-20°C或-80°C，尽量减少反复冻融循环。
计算结果:
工作液浓度： mg/mL；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL)。如该浓度超过该批次药物DMSO溶解度，请首先与我们联系。
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
(1) 请确保溶液澄清之后，再加入下一种溶剂 (助溶剂) 。可利用涡旋、超声或水浴加热等方法助溶；
(2) 一定要按顺序加入溶剂 (助溶剂) 。
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02624362 | ENROLLING BY INVITATION | Behavioral: Therapeutic Suggestion Behavioral: Asthmogenic Suggestion Other: Phenylethyl Alcohol odor |
Asthma | Universitaire Ziekenhuizen KU Leuven | 2015-08 | Not Applicable |
| NCT05908318 | NOT YET RECRUITING | Behavioral: olfactory training | Postoperative Delirium Preoperative Olfactory Training |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2023-07 | Not Applicable |
| NCT06290219 | NOT YET RECRUITING | Combination Product: platelet-rich plasma combined with hyaluronic acid Drug: Zinc Gluconate 10 MG Oral Tablet Device: 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil |
Effect of Drug Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis) | Taichung Veterans General Hospital | 2024-03-20 | Phase 3 |
| NCT01380691 | COMPLETEDWITH RESULTS | Drug: LY2216684 Drug: Placebo-matching LY2216684 Drug: Placebo-matching alcoholic beverage Drug: Alcoholic beverage |
Major Depressive Disorder | Eli Lilly and Company | 2011-06 | Phase 1 |
| NCT06066307 | RECRUITING | Other: Olfactory training | Loss of Smell Olfactory Disorder | Leigh Sowerby | 2023-09-25 | Phase 4 |
PHPS1 Sodium
BE 2254
环胞啶硫酸盐
Azido-PEG5-acid
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